The Science Behind TargetCool

TargetCool Boosting specifically targets the dermal-epidermal junction (DEJ) to deliver benefits by promoting rapid absorption in both the epidermis and dermis. This reinforces skin layer connections and can potentially combat ageing effects like wrinkles and loss of elasticity, yielding quick results.
MTS + TargetCool
TargetCoolshowed a 252% increase in fluorescent intensity and a 37% increase in penetration depth compared to the negative control group. MTS + TargetCool showed the highest level of fluorescence intensity and penetration depth.


Needleless Cooling Delivery System


What is the DEJ?
The DEJ is the utmost upper part of the dermal layer that provides strong cohesion between the epidermis and the dermis, ultimately enhancing the skin’s resilience.

Benefits of CO2 Cooling
1) Reduce inflammation: CO2regulates NF-kappa B, which induces the expression of genes that cause inflammation.
2) Improvement of blood circulation: CO2induces vasodilation, providing nutrients and oxygen to the skin tissue.
3) Oxygen supply: CO2 lowers blood pH and induces the Bohr effect to supply oxygen to cell tissues.
4) Formation of blood vessels: Increase vascular endothelial growth factor to form new blood
Before CO₂ spray detected | After 1 minute of CO₂ spray detected | After 2 minutes of CO₂ spray detected |
CO₂ detection in the epidermis | CO₂ detection in the epidermis and upper dermis |
Ultimately CO₂ diffuses and reaches the dermis with TargetCool